Natural Factors Methylfolate plus B12Natural Factors Methylfolate Plus Methylcobalamin is an innovative one a day formula that provides 1000 mcg of folate and 50 mcg of vitamin B12 alongside Farm Fresh Factors a bioenergetic blend of phytonutrients to help prevent folate deficiency. Research has shown that Quatrefolic, the metabolically active and coenzymated form of folate, results in a 3. 1 times higher blood folate concentration of 5 MTHF than regular folic acid. Feel the difference!