HCL-Pepsin SAPDigestive support (science based) Betaine (trimethylglycine) is an essential human nutrient present in most tissues and synthesized endogenously from choline in the liver and kidneys. Betaine plays several important biological roles, including as an osmoprotectant, methyl group donor, reducing plasma homocysteine levels, and ameliorating inflammation and oxidative stress. Hypochlorhydria is common in several medical conditions, including Helicobacter